Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3781579..3782120 Replicon chromosome
Accession NZ_LR778150
Organism Escherichia coli isolate SC492

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag H1C91_RS18135 Protein ID WP_097757820.1
Coordinates 3781842..3782120 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag H1C91_RS18130 Protein ID WP_000729704.1
Coordinates 3781579..3781839 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C91_RS18105 3776615..3777754 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
H1C91_RS18110 3777738..3779831 + 2094 WP_073446310.1 flagellar biosynthesis protein FlhA -
H1C91_RS18115 3779936..3780214 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
H1C91_RS18120 3780207..3780563 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
H1C91_RS18125 3780620..3781393 - 774 WP_123058776.1 C40 family peptidase -
H1C91_RS18130 3781579..3781839 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
H1C91_RS18135 3781842..3782120 + 279 WP_097757820.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
H1C91_RS18140 3782276..3783016 + 741 WP_001225679.1 murein L,D-transpeptidase -
H1C91_RS18145 3782987..3783754 - 768 WP_000333380.1 class II glutamine amidotransferase -
H1C91_RS18150 3783960..3784538 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.64 Da        Isoelectric Point: 10.0702

>T289257 WP_097757820.1 NZ_LR778150:3781842-3782120 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVELDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT289257 WP_000729704.1 NZ_LR778150:3781579-3781839 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References