Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1951386..1951888 Replicon chromosome
Accession NZ_LR778150
Organism Escherichia coli isolate SC492

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H1C91_RS09290 Protein ID WP_000767829.1
Coordinates 1951634..1951888 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag H1C91_RS09285 Protein ID WP_001259255.1
Coordinates 1951386..1951637 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C91_RS09260 1946564..1947631 - 1068 WP_000080117.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
H1C91_RS09265 1947631..1948701 - 1071 WP_001099214.1 histidinol-phosphate transaminase -
H1C91_RS09270 1948698..1950002 - 1305 WP_001358504.1 histidinol dehydrogenase -
H1C91_RS09275 1950008..1950907 - 900 WP_000131792.1 ATP phosphoribosyltransferase -
H1C91_RS09280 1951053..1951103 - 51 WP_001364200.1 his operon leader peptide -
H1C91_RS09285 1951386..1951637 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H1C91_RS09290 1951634..1951888 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H1C91_RS09295 1951971..1952795 + 825 WP_000754758.1 SDR family oxidoreductase -
H1C91_RS09300 1952841..1953770 + 930 WP_000803351.1 LysR family transcriptional regulator -
H1C91_RS09305 1953985..1954047 + 63 WP_010723108.1 membrane protein YoeI -
H1C91_RS09310 1954037..1955395 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H1C91_RS09315 1955574..1956632 + 1059 WP_000492340.1 transport protein YeeE -
H1C91_RS09320 1956646..1956873 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289249 WP_000767829.1 NZ_LR778150:1951634-1951888 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289249 WP_001259255.1 NZ_LR778150:1951386-1951637 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References