Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2891740..2892342 Replicon chromosome
Accession NZ_LR778149
Organism Escherichia coli isolate SC487

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag H1C96_RS13890 Protein ID WP_000897305.1
Coordinates 2892031..2892342 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H1C96_RS13885 Protein ID WP_000356397.1
Coordinates 2891740..2892030 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C96_RS13860 2887666..2888568 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
H1C96_RS13865 2888565..2889200 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
H1C96_RS13870 2889197..2890126 + 930 WP_000027706.1 formate dehydrogenase accessory protein FdhE -
H1C96_RS13875 2890456..2890698 - 243 WP_001087409.1 hypothetical protein -
H1C96_RS13880 2890917..2891135 - 219 WP_001295676.1 ribbon-helix-helix domain-containing protein -
H1C96_RS13885 2891740..2892030 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
H1C96_RS13890 2892031..2892342 - 312 WP_000897305.1 hypothetical protein Toxin
H1C96_RS13895 2892571..2893479 + 909 WP_001162704.1 alpha/beta hydrolase -
H1C96_RS13900 2893543..2894484 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
H1C96_RS13905 2894529..2894966 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
H1C96_RS13910 2894963..2895835 - 873 WP_000920762.1 virulence factor BrkB family protein -
H1C96_RS13915 2895829..2896428 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T289237 WP_000897305.1 NZ_LR778149:c2892342-2892031 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT289237 WP_000356397.1 NZ_LR778149:c2892030-2891740 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References