Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 98715..99217 Replicon chromosome
Accession NZ_LR778149
Organism Escherichia coli isolate SC487

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H1C96_RS00495 Protein ID WP_000767829.1
Coordinates 98963..99217 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag H1C96_RS00490 Protein ID WP_001259255.1
Coordinates 98715..98966 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C96_RS00465 93893..94960 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
H1C96_RS00470 94960..96030 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
H1C96_RS00475 96027..97331 - 1305 WP_063121251.1 histidinol dehydrogenase -
H1C96_RS00480 97337..98236 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
H1C96_RS00485 98382..98432 - 51 WP_001364200.1 his operon leader peptide -
H1C96_RS00490 98715..98966 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H1C96_RS00495 98963..99217 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H1C96_RS00500 99300..100124 + 825 WP_000754752.1 SDR family oxidoreductase -
H1C96_RS00505 100170..101099 + 930 WP_000803351.1 LysR family transcriptional regulator -
H1C96_RS00510 101314..101376 + 63 WP_010723108.1 membrane protein YoeI -
H1C96_RS00515 101366..102724 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H1C96_RS00520 102903..103961 + 1059 WP_023568741.1 transport protein YeeE -
H1C96_RS00525 103975..104202 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289227 WP_000767829.1 NZ_LR778149:98963-99217 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289227 WP_001259255.1 NZ_LR778149:98715-98966 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References