Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4121250..4121752 Replicon chromosome
Accession NZ_LR778148
Organism Escherichia coli isolate SC475

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H1C74_RS19835 Protein ID WP_000767829.1
Coordinates 4121250..4121504 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag H1C74_RS19840 Protein ID WP_001259255.1
Coordinates 4121501..4121752 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C74_RS19805 4116265..4116492 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
H1C74_RS19810 4116506..4117564 - 1059 WP_000492304.1 transport protein YeeE -
H1C74_RS19815 4117743..4119101 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H1C74_RS19820 4119091..4119153 - 63 WP_010723108.1 membrane protein YoeI -
H1C74_RS19825 4119368..4120297 - 930 WP_000803350.1 LysR family transcriptional regulator -
H1C74_RS19830 4120343..4121167 - 825 WP_000754749.1 SDR family oxidoreductase -
H1C74_RS19835 4121250..4121504 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H1C74_RS19840 4121501..4121752 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H1C74_RS19845 4122035..4122085 + 51 WP_001364200.1 his operon leader peptide -
H1C74_RS19850 4122231..4123130 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
H1C74_RS19855 4123136..4124440 + 1305 WP_047083378.1 histidinol dehydrogenase -
H1C74_RS19860 4124437..4125507 + 1071 WP_001297360.1 histidinol-phosphate transaminase -
H1C74_RS19865 4125507..4126574 + 1068 WP_000080096.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289225 WP_000767829.1 NZ_LR778148:c4121504-4121250 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289225 WP_001259255.1 NZ_LR778148:c4121752-4121501 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References