Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2189446..2189987 Replicon chromosome
Accession NZ_LR778148
Organism Escherichia coli isolate SC475

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag H1C74_RS10345 Protein ID WP_000615976.1
Coordinates 2189446..2189724 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag H1C74_RS10350 Protein ID WP_000729704.1
Coordinates 2189727..2189987 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C74_RS10330 2187028..2187606 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
H1C74_RS10335 2187812..2188579 + 768 WP_000333380.1 class II glutamine amidotransferase -
H1C74_RS10340 2188550..2189290 - 741 WP_001225679.1 murein L,D-transpeptidase -
H1C74_RS10345 2189446..2189724 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
H1C74_RS10350 2189727..2189987 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
H1C74_RS10355 2190173..2190946 + 774 WP_000543899.1 C40 family peptidase -
H1C74_RS10360 2191003..2191359 - 357 WP_001030482.1 type II toxin-antitoxin system HicB family antitoxin -
H1C74_RS10365 2191352..2191630 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
H1C74_RS10370 2191735..2193447 - 1713 Protein_2007 flagellar biosynthesis protein FlhA -
H1C74_RS10375 2193419..2194204 + 786 WP_000207574.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T289216 WP_000615976.1 NZ_LR778148:c2189724-2189446 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT289216 WP_000729704.1 NZ_LR778148:c2189987-2189727 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References