Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2574871..2575373 Replicon chromosome
Accession NZ_LR778147
Organism Escherichia coli isolate SC418

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H1D11_RS12120 Protein ID WP_000767829.1
Coordinates 2575119..2575373 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag H1D11_RS12115 Protein ID WP_025210604.1
Coordinates 2574871..2575122 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D11_RS12090 2570049..2571116 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
H1D11_RS12095 2571116..2572186 - 1071 WP_115423397.1 histidinol-phosphate transaminase -
H1D11_RS12100 2572183..2573487 - 1305 WP_115423396.1 histidinol dehydrogenase -
H1D11_RS12105 2573493..2574392 - 900 WP_096931067.1 ATP phosphoribosyltransferase -
H1D11_RS12110 2574538..2574588 - 51 WP_001364200.1 his operon leader peptide -
H1D11_RS12115 2574871..2575122 + 252 WP_025210604.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H1D11_RS12120 2575119..2575373 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H1D11_RS12125 2575456..2576280 + 825 WP_000754737.1 SDR family oxidoreductase -
H1D11_RS12130 2576326..2577255 + 930 WP_000803351.1 LysR family transcriptional regulator -
H1D11_RS12135 2577470..2577532 + 63 WP_010723108.1 membrane protein YoeI -
H1D11_RS12140 2577522..2578880 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H1D11_RS12145 2579059..2580117 + 1059 WP_000492321.1 transport protein YeeE -
H1D11_RS12150 2580131..2580358 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289196 WP_000767829.1 NZ_LR778147:2575119-2575373 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9249.55 Da        Isoelectric Point: 5.0930

>AT289196 WP_025210604.1 NZ_LR778147:2574871-2575122 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIGSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References