Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1143552..1144351 Replicon chromosome
Accession NZ_LR778147
Organism Escherichia coli isolate SC418

Toxin (Protein)


Gene name yhaV Uniprot ID A0A1M2ER85
Locus tag H1D11_RS05285 Protein ID WP_032352641.1
Coordinates 1143552..1144016 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A1M2ER73
Locus tag H1D11_RS05290 Protein ID WP_032352640.1
Coordinates 1144016..1144351 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D11_RS05255 1138553..1138987 - 435 WP_000948818.1 PTS sugar transporter subunit IIA -
H1D11_RS05260 1139005..1139883 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
H1D11_RS05265 1139873..1140652 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
H1D11_RS05270 1140663..1141136 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
H1D11_RS05275 1141159..1142439 - 1281 WP_032352643.1 tagatose-bisphosphate aldolase subunit KbaZ -
H1D11_RS05280 1142688..1143497 + 810 WP_096131879.1 aga operon transcriptional regulator AgaR -
H1D11_RS05285 1143552..1144016 - 465 WP_032352641.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
H1D11_RS05290 1144016..1144351 - 336 WP_032352640.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
H1D11_RS05295 1144500..1146071 - 1572 WP_001273756.1 galactarate dehydratase -
H1D11_RS05300 1146446..1147780 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
H1D11_RS05305 1147796..1148566 + 771 WP_001551692.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1143552..1154840 11288


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17814.20 Da        Isoelectric Point: 9.4942

>T289192 WP_032352641.1 NZ_LR778147:c1144016-1143552 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETD

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12416.98 Da        Isoelectric Point: 4.6890

>AT289192 WP_032352640.1 NZ_LR778147:c1144351-1144016 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPDGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2ER85

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2ER73

References