Detailed information of TA system TA289181

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3677195..3677417
• Replicon: chromosome
• Accession: NZ_LR778146
• Organism: Escherichia coli isolate SC455

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: H1D08_RS17800
• Protein ID: WP_001295224.1
• Coordinates: 3677310..3677417 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3677195..3677261 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1D08_RS17770	3672199..3673212	+	1014	WP_053898372.1	dipeptide ABC transporter ATP-binding subunit DppF	-
H1D08_RS17775	3673437..3673760	+	324	WP_000563102.1	helix-turn-helix transcriptional regulator	-
H1D08_RS17780	3673745..3674056	+	312	WP_001490601.1	HipA N-terminal domain-containing protein	-
H1D08_RS17785	3674056..3675063	+	1008	WP_024225716.1	HipA domain-containing protein	-
H1D08_RS17790	3675080..3676351	-	1272	WP_001312176.1	amino acid permease	-
H1D08_RS17795	3676827..3676934	+	108	WP_000170747.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	3677195..3677261	-	67	-	-	Antitoxin
H1D08_RS17800	3677310..3677417	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
H1D08_RS17805	3677503..3679182	-	1680	WP_000191568.1	cellulose biosynthesis protein BcsG	-
H1D08_RS17810	3679179..3679370	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
H1D08_RS17815	3679367..3680938	-	1572	WP_175058660.1	cellulose biosynthesis protein BcsE	-
H1D08_RS17820	3681211..3681399	+	189	WP_001063314.1	YhjR family protein	-
H1D08_RS17825	3681411..3682163	+	753	WP_175058661.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T289181 WP_001295224.1 NZ_LR778146:3677310-3677417 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

Antitoxin

Nucleotide

• Length: 67 bp

>AT289181 NZ_LR778146:c3677261-3677195 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin