Detailed information of TA system TA289180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 3673745..3675063
• Replicon: chromosome
• Accession: NZ_LR778146
• Organism: Escherichia coli isolate SC455

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: H1D08_RS17785
• Protein ID: WP_024225716.1
• Coordinates: 3674056..3675063 (+)
• Length: 336 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A2A7M399
• Locus tag: H1D08_RS17780
• Protein ID: WP_001490601.1
• Coordinates: 3673745..3674056 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1D08_RS17755	3669277..3670296	+	1020	WP_000938855.1	dipeptide ABC transporter permease DppB	-
H1D08_RS17760	3670306..3671208	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
H1D08_RS17765	3671219..3672202	+	984	WP_112886706.1	dipeptide ABC transporter ATP-binding protein	-
H1D08_RS17770	3672199..3673212	+	1014	WP_053898372.1	dipeptide ABC transporter ATP-binding subunit DppF	-
H1D08_RS17775	3673437..3673760	+	324	WP_000563102.1	helix-turn-helix transcriptional regulator	-
H1D08_RS17780	3673745..3674056	+	312	WP_001490601.1	HipA N-terminal domain-containing protein	Antitoxin
H1D08_RS17785	3674056..3675063	+	1008	WP_024225716.1	HipA domain-containing protein	Toxin
H1D08_RS17790	3675080..3676351	-	1272	WP_001312176.1	amino acid permease	-
H1D08_RS17795	3676827..3676934	+	108	WP_000170747.1	type I toxin-antitoxin system toxin Ldr family protein	-
H1D08_RS17800	3677310..3677417	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
H1D08_RS17805	3677503..3679182	-	1680	WP_000191568.1	cellulose biosynthesis protein BcsG	-
H1D08_RS17810	3679179..3679370	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-302)

Antitoxin

• HipA, N-terminal subdomain 1 (6-98)

Sequences

Toxin

Protein

• Length: 336 a.a.
• Molecular weight: 38384.63 Da
• Isoelectric Point: 5.6166

>T289180 WP_024225716.1 NZ_LR778146:3674056-3675063 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLNEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVSVHGLLSFAPQSEEELEYAFVIRRYDRDYKGLPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPTLAPVYDFVSVAPY
PEYFYSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Nucleotide

• Length: 1008 bp

>T289180 NZ_LR778146:3674056-3675063 [Escherichia coli]
ATGGCGAATTGTCGTATTCTGTTAACGCCGTTGAATGAACGTGACGAACAGCGCGGATATTCGACACAGGGGTTGAAGCG
ACTGAGCGGCACTGCAAAATTGACCCCCAGGCTGGGGTTTACGCGAACTCAGTTTGTGCAGGAACTTCCGCGTCAACAAA
AAGGGATGAGTATTTCCGGTTACCAGCCCAAATTGCAATTAGTGCTGAATGAAGGAGAGTTCCGCGTCGTAGATCATCAG
GGAAATTTTATCCTTAAGCCCTCTCCAGCCGACTTTCCCGGCTTGGCCGAAAATGAACACGCAACAATGACATTGATGTC
TCGTTTGGGATTTGACGTATCTGTGCATGGCCTGTTGAGTTTTGCACCACAATCAGAGGAAGAGCTTGAATACGCATTTG
TTATCCGGCGCTATGACCGGGATTACAAGGGGCTGCCAGTGCATCAGGAACAGCTTGATGGCGCGATGCAGATTACAGAT
AAATATGGCAAAACGGGGAATGATAACGAACAATATGTCAGCTATGAAACGCTGGCCCGATTTTTAGTTGCCCATGTTAA
CGACAACATCGCATTTAAAATCGATCTCTTTCGTCGCATTGTTTACGCCTGGTTGCTGGGTAATAACGACATGCATTTAC
GAAACTTTGGTTTAGTGTACTCCGATGGTTTGACGCCAACGTTAGCGCCGGTGTATGACTTTGTTTCTGTCGCTCCCTAT
CCGGAATATTTTTACTCAAACTATCTGGCGCTGCCGTTATTGACGCGAGAAGAAGGCGGTCGGGAACTGGCTCCTGGATT
TCACAGTGATTATGGCGAGTATATCGGGCAGGACTTTTTGCTGTTGGGTGAATCAATGGGGTTAGCGCCCAGATTGCTGG
AAAAACTCTTTCAGGATATACGTAAAGAAAATGCCATTGTTATGGAAACGTATGAGCAGTCCTTTATGACTCAGGATCAT
ATCCAGGCTGTGCTGCAATGCTATCGACATCGTCTGGGGCTGCTGTGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11822.40 Da
• Isoelectric Point: 6.0609

>AT289180 WP_001490601.1 NZ_LR778146:3673745-3674056 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAQDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Nucleotide

• Length: 312 bp

>AT289180 NZ_LR778146:3673745-3674056 [Escherichia coli]
ATGCATCGGCGAGTGAAAGTGTTGCTCTATGGTCAGGTAGTGGGTGAACTCTCTCAGAACGACAGTGGTTTTTTGTTCCA
GTACGCCCAGGATTACCACGGACCGGCAATCTCAATCAGCCTGCCCGTCGCACAGCGTCAGTTTCCCAGTGAGACGTTGC
ATCCTTATTTCGCCTCACTGGCGCCAGAAGGATGGCTGCGTCAACGCTACAGCCAGATACAGCATCGTGACGAAAACGAT
CTGCTGGGAATGCTTATTGATAACGGCAAGAATCTGCTGGGGGCAATCCAGATTTTACCTTGGGAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A2A7M399