Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 2366242..2366936 Replicon chromosome
Accession NZ_LR778146
Organism Escherichia coli isolate SC455

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag H1D08_RS11635 Protein ID WP_001263500.1
Coordinates 2366242..2366640 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag H1D08_RS11640 Protein ID WP_000554758.1
Coordinates 2366643..2366936 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D08_RS11610 2361551..2362009 - 459 WP_001291991.1 xanthine phosphoribosyltransferase -
H1D08_RS11615 2362270..2363727 + 1458 WP_175058567.1 cytosol nonspecific dipeptidase -
H1D08_RS11620 2363784..2364398 - 615 WP_000602123.1 peptide chain release factor H -
H1D08_RS11625 2364395..2365534 - 1140 WP_180344730.1 RNA ligase RtcB family protein -
H1D08_RS11630 2365780..2366232 - 453 WP_089573738.1 GNAT family N-acetyltransferase -
H1D08_RS11635 2366242..2366640 - 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
H1D08_RS11640 2366643..2366936 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
H1D08_RS11645 2366988..2368043 - 1056 WP_001226166.1 DNA polymerase IV -
H1D08_RS11650 2368114..2369037 - 924 WP_060578024.1 putative lateral flagellar export/assembly protein LafU -
H1D08_RS11655 2369040..2369903 - 864 WP_001169518.1 flagellar motor stator protein MotA -
H1D08_RS11660 2369916..2370632 - 717 WP_000938731.1 FliA/WhiG family RNA polymerase sigma factor -
H1D08_RS11665 2370652..2371119 - 468 WP_000725261.1 flagellar basal body-associated FliL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T289176 WP_001263500.1 NZ_LR778146:c2366640-2366242 [Escherichia coli]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT289176 WP_000554758.1 NZ_LR778146:c2366936-2366643 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PJQ2

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References