Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4041027..4041568 Replicon chromosome
Accession NZ_LR778145
Organism Escherichia coli isolate SC423

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag H1C75_RS19325 Protein ID WP_000615976.1
Coordinates 4041290..4041568 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag H1C75_RS19320 Protein ID WP_000729704.1
Coordinates 4041027..4041287 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C75_RS19295 4036063..4037202 + 1140 WP_104716369.1 flagellar type III secretion system protein FlhB -
H1C75_RS19300 4037186..4039279 + 2094 WP_001597626.1 flagellar biosynthesis protein FlhA -
H1C75_RS19305 4039384..4039662 + 279 WP_000598758.1 type II toxin-antitoxin system HicA family toxin -
H1C75_RS19310 4039655..4040011 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
H1C75_RS19315 4040068..4040841 - 774 WP_000543899.1 C40 family peptidase -
H1C75_RS19320 4041027..4041287 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
H1C75_RS19325 4041290..4041568 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
H1C75_RS19330 4041724..4042464 + 741 WP_001225679.1 murein L,D-transpeptidase -
H1C75_RS19335 4042435..4043202 - 768 WP_000333380.1 class II glutamine amidotransferase -
H1C75_RS19340 4043408..4043986 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 4039655..4052354 12699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T289165 WP_000615976.1 NZ_LR778145:4041290-4041568 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT289165 WP_000729704.1 NZ_LR778145:4041027-4041287 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References