Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3446498..3447000 Replicon chromosome
Accession NZ_LR778143
Organism Escherichia coli isolate SC422

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H1C98_RS16390 Protein ID WP_000767829.1
Coordinates 3446746..3447000 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag H1C98_RS16385 Protein ID WP_001259255.1
Coordinates 3446498..3446749 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C98_RS16360 3441676..3442743 - 1068 WP_000080087.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
H1C98_RS16365 3442743..3443813 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
H1C98_RS16370 3443810..3445114 - 1305 WP_001315708.1 histidinol dehydrogenase -
H1C98_RS16375 3445120..3446019 - 900 WP_000131792.1 ATP phosphoribosyltransferase -
H1C98_RS16380 3446165..3446215 - 51 WP_001364200.1 his operon leader peptide -
H1C98_RS16385 3446498..3446749 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H1C98_RS16390 3446746..3447000 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H1C98_RS16395 3447083..3447907 + 825 WP_000754749.1 SDR family oxidoreductase -
H1C98_RS16400 3447953..3448882 + 930 WP_000803351.1 LysR family transcriptional regulator -
H1C98_RS16405 3449097..3449159 + 63 WP_010723108.1 membrane protein YoeI -
H1C98_RS16410 3449149..3450507 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H1C98_RS16415 3450686..3451744 + 1059 WP_000492346.1 transport protein YeeE -
H1C98_RS16420 3451758..3451985 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289145 WP_000767829.1 NZ_LR778143:3446746-3447000 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289145 WP_001259255.1 NZ_LR778143:3446498-3446749 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References