Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1297887..1298489 Replicon chromosome
Accession NZ_LR778143
Organism Escherichia coli isolate SC422

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag H1C98_RS06170 Protein ID WP_000897305.1
Coordinates 1298178..1298489 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H1C98_RS06165 Protein ID WP_000356397.1
Coordinates 1297887..1298177 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C98_RS06140 1293812..1294714 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
H1C98_RS06145 1294711..1295346 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
H1C98_RS06150 1295343..1296272 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
H1C98_RS06155 1296602..1296844 - 243 WP_001087409.1 hypothetical protein -
H1C98_RS06160 1297064..1297282 - 219 WP_001315930.1 ribbon-helix-helix domain-containing protein -
H1C98_RS06165 1297887..1298177 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
H1C98_RS06170 1298178..1298489 - 312 WP_000897305.1 hypothetical protein Toxin
H1C98_RS06175 1298718..1299626 + 909 WP_001162704.1 alpha/beta hydrolase -
H1C98_RS06180 1299690..1300631 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
H1C98_RS06185 1300676..1301113 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
H1C98_RS06190 1301110..1301982 - 873 WP_000920762.1 virulence factor BrkB family protein -
H1C98_RS06195 1301976..1302575 - 600 WP_001295269.1 glucose-1-phosphatase -
H1C98_RS06200 1302674..1303459 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T289137 WP_000897305.1 NZ_LR778143:c1298489-1298178 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT289137 WP_000356397.1 NZ_LR778143:c1298177-1297887 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References