Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 378612..379153 Replicon chromosome
Accession NZ_LR778143
Organism Escherichia coli isolate SC422

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag H1C98_RS01965 Protein ID WP_000615976.1
Coordinates 378875..379153 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag H1C98_RS01960 Protein ID WP_000729704.1
Coordinates 378612..378872 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C98_RS01935 374394..375179 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
H1C98_RS01940 375151..376863 + 1713 Protein_384 flagellar biosynthesis protein FlhA -
H1C98_RS01945 377023..377247 + 225 WP_001339266.1 type II toxin-antitoxin system HicA family toxin -
H1C98_RS01950 377240..377596 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
H1C98_RS01955 377653..378426 - 774 WP_000543895.1 C40 family peptidase -
H1C98_RS01960 378612..378872 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
H1C98_RS01965 378875..379153 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
H1C98_RS01970 379309..380049 + 741 WP_001225679.1 murein L,D-transpeptidase -
H1C98_RS01975 380020..380787 - 768 WP_000333380.1 class II glutamine amidotransferase -
H1C98_RS01980 380993..381571 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T289133 WP_000615976.1 NZ_LR778143:378875-379153 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT289133 WP_000729704.1 NZ_LR778143:378612-378872 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References