289129

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 4110315..4111633 Replicon chromosome
Accession NZ_LR778142
Organism Escherichia coli isolate SC434

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag H1D10_RS20010 Protein ID WP_024225716.1
Coordinates 4110315..4111322 (-) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2A7M399
Locus tag H1D10_RS20015 Protein ID WP_001490601.1
Coordinates 4111322..4111633 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D10_RS19985 4106008..4106199 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
H1D10_RS19990 4106196..4107875 + 1680 WP_000191568.1 cellulose biosynthesis protein BcsG -
H1D10_RS19995 4107961..4108068 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
H1D10_RS20000 4108444..4108551 - 108 WP_000170747.1 type I toxin-antitoxin system toxin Ldr family protein -
H1D10_RS20005 4109027..4110298 + 1272 WP_001312176.1 amino acid permease -
H1D10_RS20010 4110315..4111322 - 1008 WP_024225716.1 HipA domain-containing protein Toxin
H1D10_RS20015 4111322..4111633 - 312 WP_001490601.1 HipA N-terminal domain-containing protein Antitoxin
H1D10_RS20020 4111618..4111941 - 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
H1D10_RS20025 4112166..4113179 - 1014 WP_053898372.1 dipeptide ABC transporter ATP-binding subunit DppF -
H1D10_RS20030 4113176..4114159 - 984 WP_112886706.1 dipeptide ABC transporter ATP-binding protein -
H1D10_RS20035 4114170..4115072 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
H1D10_RS20040 4115082..4116101 - 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38384.63 Da        Isoelectric Point: 5.6166

>T289129 WP_024225716.1 NZ_LR778142:c4111322-4110315 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLNEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVSVHGLLSFAPQSEEELEYAFVIRRYDRDYKGLPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPTLAPVYDFVSVAPY
PEYFYSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11822.40 Da        Isoelectric Point: 6.0609

>AT289129 WP_001490601.1 NZ_LR778142:c4111633-4111322 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAQDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7M399

References