Detailed information of TA system TA289128

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4108444..4108666
• Replicon: chromosome
• Accession: NZ_LR778142
• Organism: Escherichia coli isolate SC434

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: B7UL94
• Locus tag: H1D10_RS20000
• Protein ID: WP_000170747.1
• Coordinates: 4108444..4108551 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4108600..4108666 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1D10_RS19975	4103979..4104167	-	189	WP_001063314.1	YhjR family protein	-
H1D10_RS19980	4104440..4106011	+	1572	WP_175058660.1	cellulose biosynthesis protein BcsE	-
H1D10_RS19985	4106008..4106199	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
H1D10_RS19990	4106196..4107875	+	1680	WP_000191568.1	cellulose biosynthesis protein BcsG	-
H1D10_RS19995	4107961..4108068	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
H1D10_RS20000	4108444..4108551	-	108	WP_000170747.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4108600..4108666	+	67	-	-	Antitoxin
H1D10_RS20005	4109027..4110298	+	1272	WP_001312176.1	amino acid permease	-
H1D10_RS20010	4110315..4111322	-	1008	WP_024225716.1	HipA domain-containing protein	-
H1D10_RS20015	4111322..4111633	-	312	WP_001490601.1	HipA N-terminal domain-containing protein	-
H1D10_RS20020	4111618..4111941	-	324	WP_000563102.1	helix-turn-helix transcriptional regulator	-
H1D10_RS20025	4112166..4113179	-	1014	WP_053898372.1	dipeptide ABC transporter ATP-binding subunit DppF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3910.76 Da
• Isoelectric Point: 9.0157

>T289128 WP_000170747.1 NZ_LR778142:c4108551-4108444 [Escherichia coli]
MTLAELGMAFWHDLAVPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

Antitoxin

Nucleotide

• Length: 67 bp

>AT289128 NZ_LR778142:4108600-4108666 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0K5IMN1

Antitoxin