Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3683266..3684065 Replicon chromosome
Accession NZ_LR778142
Organism Escherichia coli isolate SC434

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag H1D10_RS17885 Protein ID WP_087598199.1
Coordinates 3683601..3684065 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag H1D10_RS17880 Protein ID WP_087598198.1
Coordinates 3683266..3683601 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D10_RS17865 3679051..3679821 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
H1D10_RS17870 3679837..3681171 - 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
H1D10_RS17875 3681546..3683117 + 1572 WP_001273940.1 galactarate dehydratase -
H1D10_RS17880 3683266..3683601 + 336 WP_087598198.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
H1D10_RS17885 3683601..3684065 + 465 WP_087598199.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
H1D10_RS17890 3684120..3684929 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
H1D10_RS17895 3685178..3686458 + 1281 WP_137527028.1 tagatose-bisphosphate aldolase subunit KbaZ -
H1D10_RS17900 3686481..3686954 + 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
H1D10_RS17905 3686965..3687744 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
H1D10_RS17910 3687734..3688612 + 879 WP_001298314.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
H1D10_RS17915 3688630..3689064 + 435 WP_137527029.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17811.16 Da        Isoelectric Point: 9.4947

>T289125 WP_087598199.1 NZ_LR778142:3683601-3684065 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDAFVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12303.88 Da        Isoelectric Point: 4.5392

>AT289125 WP_087598198.1 NZ_LR778142:3683266-3683601 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFLCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References