Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2499918..2500420 Replicon chromosome
Accession NZ_LR778142
Organism Escherichia coli isolate SC434

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H1D10_RS12460 Protein ID WP_000767829.1
Coordinates 2499918..2500172 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag H1D10_RS12465 Protein ID WP_001259255.1
Coordinates 2500169..2500420 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D10_RS12440 2496411..2497769 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H1D10_RS12445 2497759..2497821 - 63 WP_010723108.1 membrane protein YoeI -
H1D10_RS12450 2498036..2498965 - 930 WP_000803366.1 LysR family transcriptional regulator -
H1D10_RS12455 2499011..2499835 - 825 WP_000754737.1 SDR family oxidoreductase -
H1D10_RS12460 2499918..2500172 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H1D10_RS12465 2500169..2500420 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H1D10_RS12470 2500703..2500753 + 51 WP_001364200.1 his operon leader peptide -
H1D10_RS12475 2500899..2501798 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
H1D10_RS12480 2501804..2503108 + 1305 WP_175058405.1 histidinol dehydrogenase -
H1D10_RS12485 2503105..2504175 + 1071 WP_175058404.1 histidinol-phosphate transaminase -
H1D10_RS12490 2504175..2505242 + 1068 WP_175058403.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289121 WP_000767829.1 NZ_LR778142:c2500172-2499918 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289121 WP_001259255.1 NZ_LR778142:c2500420-2500169 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References