Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3816422..3817024 Replicon chromosome
Accession NZ_LR778141
Organism Escherichia coli isolate SC407

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag H1C92_RS18620 Protein ID WP_000897305.1
Coordinates 3816422..3816733 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H1C92_RS18625 Protein ID WP_000356397.1
Coordinates 3816734..3817024 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C92_RS18590 3811452..3812237 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
H1C92_RS18595 3812336..3812935 + 600 WP_001295269.1 glucose-1-phosphatase -
H1C92_RS18600 3812929..3813801 + 873 WP_000920762.1 virulence factor BrkB family protein -
H1C92_RS18605 3813798..3814235 + 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
H1C92_RS18610 3814280..3815221 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
H1C92_RS18615 3815285..3816193 - 909 WP_001162704.1 alpha/beta hydrolase -
H1C92_RS18620 3816422..3816733 + 312 WP_000897305.1 hypothetical protein Toxin
H1C92_RS18625 3816734..3817024 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
H1C92_RS18630 3817629..3817847 + 219 WP_001315930.1 ribbon-helix-helix domain-containing protein -
H1C92_RS18635 3818067..3818309 + 243 WP_001087409.1 hypothetical protein -
H1C92_RS18640 3818639..3819568 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
H1C92_RS18645 3819565..3820200 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
H1C92_RS18650 3820197..3821099 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T289104 WP_000897305.1 NZ_LR778141:3816422-3816733 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT289104 WP_000356397.1 NZ_LR778141:3816734-3817024 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References