Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1671822..1672324 Replicon chromosome
Accession NZ_LR778141
Organism Escherichia coli isolate SC407

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H1C92_RS08535 Protein ID WP_000767829.1
Coordinates 1671822..1672076 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag H1C92_RS08540 Protein ID WP_001259255.1
Coordinates 1672073..1672324 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C92_RS08505 1666837..1667064 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
H1C92_RS08510 1667078..1668136 - 1059 WP_000492346.1 transport protein YeeE -
H1C92_RS08515 1668315..1669673 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H1C92_RS08520 1669663..1669725 - 63 WP_010723108.1 membrane protein YoeI -
H1C92_RS08525 1669940..1670869 - 930 WP_000803351.1 LysR family transcriptional regulator -
H1C92_RS08530 1670915..1671739 - 825 WP_000754749.1 SDR family oxidoreductase -
H1C92_RS08535 1671822..1672076 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H1C92_RS08540 1672073..1672324 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H1C92_RS08545 1672607..1672657 + 51 WP_001364200.1 his operon leader peptide -
H1C92_RS08550 1672803..1673702 + 900 WP_000131792.1 ATP phosphoribosyltransferase -
H1C92_RS08555 1673708..1675012 + 1305 WP_001315708.1 histidinol dehydrogenase -
H1C92_RS08560 1675009..1676079 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
H1C92_RS08565 1676079..1677146 + 1068 WP_000080087.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289095 WP_000767829.1 NZ_LR778141:c1672076-1671822 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289095 WP_001259255.1 NZ_LR778141:c1672324-1672073 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References