Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3900753..3901294 Replicon chromosome
Accession NZ_LR778140
Organism Escherichia coli isolate SC406

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag H1C94_RS18875 Protein ID WP_000615976.1
Coordinates 3901016..3901294 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag H1C94_RS18870 Protein ID WP_000729704.1
Coordinates 3900753..3901013 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C94_RS18845 3896536..3897321 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
H1C94_RS18850 3897293..3899005 + 1713 Protein_3689 flagellar biosynthesis protein FlhA -
H1C94_RS18855 3899110..3899388 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
H1C94_RS18860 3899381..3899737 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
H1C94_RS18865 3899794..3900567 - 774 WP_000543895.1 C40 family peptidase -
H1C94_RS18870 3900753..3901013 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
H1C94_RS18875 3901016..3901294 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
H1C94_RS18880 3901450..3902190 + 741 WP_001225679.1 murein L,D-transpeptidase -
H1C94_RS18885 3902161..3902928 - 768 WP_000333380.1 class II glutamine amidotransferase -
H1C94_RS18890 3903134..3903712 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3899381..3912080 12699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T289078 WP_000615976.1 NZ_LR778140:3901016-3901294 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT289078 WP_000729704.1 NZ_LR778140:3900753-3901013 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References