Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1966700..1967202 Replicon chromosome
Accession NZ_LR778140
Organism Escherichia coli isolate SC406

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H1C94_RS09205 Protein ID WP_000767829.1
Coordinates 1966948..1967202 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag H1C94_RS09200 Protein ID WP_001259255.1
Coordinates 1966700..1966951 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C94_RS09175 1961878..1962945 - 1068 WP_000080087.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
H1C94_RS09180 1962945..1964015 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
H1C94_RS09185 1964012..1965316 - 1305 WP_001315708.1 histidinol dehydrogenase -
H1C94_RS09190 1965322..1966221 - 900 WP_000131792.1 ATP phosphoribosyltransferase -
H1C94_RS09195 1966367..1966417 - 51 WP_001364200.1 his operon leader peptide -
H1C94_RS09200 1966700..1966951 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H1C94_RS09205 1966948..1967202 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H1C94_RS09210 1967285..1968109 + 825 WP_000754749.1 SDR family oxidoreductase -
H1C94_RS09215 1968155..1969084 + 930 WP_000803351.1 LysR family transcriptional regulator -
H1C94_RS09220 1969299..1969361 + 63 WP_010723108.1 membrane protein YoeI -
H1C94_RS09225 1969351..1970709 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H1C94_RS09230 1970888..1971946 + 1059 WP_000492346.1 transport protein YeeE -
H1C94_RS09235 1971960..1972187 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289068 WP_000767829.1 NZ_LR778140:1966948-1967202 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289068 WP_001259255.1 NZ_LR778140:1966700-1966951 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References