Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 62633..62887 Replicon 1 day old chicken plasmid pAPEC2908
Accession NZ_LR740777
Organism Escherichia coli strain BEN2908 isolate

Toxin (Protein)


Gene name srnB Uniprot ID -
Locus tag APEC2908_RS25050 Protein ID WP_001351576.1
Coordinates 62633..62839 (-) Length 69 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 62826..62887 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC2908_RS25015 57708..58384 + 677 Protein_52 transposase -
APEC2908_RS25020 58384..58730 + 347 Protein_53 IS66 family insertion sequence element accessory protein TnpB -
APEC2908_RS25025 58750..60313 + 1564 Protein_54 IS66 family transposase -
APEC2908_RS25030 60461..61318 - 858 WP_161476334.1 incFII family plasmid replication initiator RepA -
APEC2908_RS25035 61311..61793 - 483 WP_001273588.1 hypothetical protein -
APEC2908_RS25040 61786..61860 - 75 WP_001442103.1 RepA leader peptide Tap -
APEC2908_RS25045 62092..62349 - 258 WP_000083845.1 replication regulatory protein RepA -
APEC2908_RS25050 62633..62839 - 207 WP_001351576.1 type I toxin-antitoxin system Hok family toxin Toxin
- 62826..62887 + 62 NuclAT_1 - Antitoxin
- 62826..62887 + 62 NuclAT_1 - Antitoxin
- 62826..62887 + 62 NuclAT_1 - Antitoxin
- 62826..62887 + 62 NuclAT_1 - Antitoxin
APEC2908_RS25055 63143..63217 - 75 Protein_60 endonuclease -
APEC2908_RS25060 63463..63675 - 213 WP_001299730.1 ANR family transcriptional regulator -
APEC2908_RS25065 63811..64371 - 561 WP_000139315.1 fertility inhibition protein FinO -
APEC2908_RS25070 64474..65334 - 861 WP_000704513.1 alpha/beta hydrolase -
APEC2908_RS25075 65393..66139 - 747 WP_021512286.1 conjugal transfer pilus acetylase TraX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..152011 152011


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(23-64)


Sequences


Toxin        


Download         Length: 69 a.a.        Molecular weight: 7826.31 Da        Isoelectric Point: 8.8807

>T289014 WP_001351576.1 NZ_LR740777:c62839-62633 [Escherichia coli]
MKYLNTTDCSLFFAERSKFMTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 207 bp


Antitoxin


Download         Length: 62 bp

>AT289014 NZ_LR740777:62826-62887 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References