Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4307033..4307635 Replicon chromosome
Accession NZ_LR740776
Organism Escherichia coli strain BEN2908 isolate

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag APEC2908_RS21065 Protein ID WP_000897302.1
Coordinates 4307033..4307344 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag APEC2908_RS21070 Protein ID WP_000356397.1
Coordinates 4307345..4307635 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC2908_RS21040 4302947..4303546 + 600 WP_001314324.1 glucose-1-phosphatase -
APEC2908_RS21045 4303540..4304412 + 873 WP_000920762.1 virulence factor BrkB family protein -
APEC2908_RS21050 4304409..4304846 + 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
APEC2908_RS21055 4304891..4305832 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
APEC2908_RS21060 4305896..4306804 - 909 WP_001331553.1 alpha/beta hydrolase -
APEC2908_RS21065 4307033..4307344 + 312 WP_000897302.1 hypothetical protein Toxin
APEC2908_RS21070 4307345..4307635 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
APEC2908_RS21075 4307994..4308272 + 279 WP_001296612.1 hypothetical protein -
APEC2908_RS21080 4308668..4308886 + 219 WP_001314326.1 ribbon-helix-helix domain-containing protein -
APEC2908_RS21085 4309102..4310031 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
APEC2908_RS21090 4310028..4310663 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
APEC2908_RS21095 4310660..4311562 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T289009 WP_000897302.1 NZ_LR740776:4307033-4307344 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT289009 WP_000356397.1 NZ_LR740776:4307345-4307635 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References