Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2159361..2159863 Replicon chromosome
Accession NZ_LR740776
Organism Escherichia coli strain BEN2908 isolate

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag APEC2908_RS10810 Protein ID WP_000767829.1
Coordinates 2159361..2159615 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag APEC2908_RS10815 Protein ID WP_001259255.1
Coordinates 2159612..2159863 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC2908_RS10780 2154376..2154603 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
APEC2908_RS10785 2154617..2155675 - 1059 WP_023568741.1 transport protein YeeE -
APEC2908_RS10790 2155854..2157212 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
APEC2908_RS10795 2157202..2157264 - 63 WP_010723108.1 membrane protein YoeI -
APEC2908_RS10800 2157479..2158408 - 930 WP_000803351.1 LysR family transcriptional regulator -
APEC2908_RS10805 2158454..2159278 - 825 WP_000754737.1 SDR family oxidoreductase -
APEC2908_RS10810 2159361..2159615 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
APEC2908_RS10815 2159612..2159863 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
APEC2908_RS10820 2160146..2160196 + 51 WP_071593552.1 his operon leader peptide -
APEC2908_RS10825 2160342..2161241 + 900 WP_000131789.1 ATP phosphoribosyltransferase -
APEC2908_RS10830 2161247..2162551 + 1305 WP_039267630.1 histidinol dehydrogenase -
APEC2908_RS10835 2162548..2163618 + 1071 WP_000108943.1 histidinol-phosphate transaminase -
APEC2908_RS10840 2163618..2164685 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289005 WP_000767829.1 NZ_LR740776:c2159615-2159361 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289005 WP_001259255.1 NZ_LR740776:c2159863-2159612 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References