Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1553626..1554188 Replicon chromosome
Accession NZ_LR740776
Organism Escherichia coli strain BEN2908 isolate

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag APEC2908_RS07655 Protein ID WP_000605675.1
Coordinates 1553910..1554188 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag APEC2908_RS07650 Protein ID WP_000781370.1
Coordinates 1553626..1553910 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC2908_RS07635 1548807..1551854 + 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -
APEC2908_RS07640 1551867..1552751 + 885 WP_001240584.1 formate dehydrogenase N subunit beta -
APEC2908_RS07645 1552744..1553397 + 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
APEC2908_RS07650 1553626..1553910 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
APEC2908_RS07655 1553910..1554188 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APEC2908_RS07660 1554374..1555384 - 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
APEC2908_RS07665 1555518..1557215 - 1698 WP_000433462.1 malate dehydrogenase -
APEC2908_RS07670 1557371..1557508 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
APEC2908_RS07675 1557610..1557825 - 216 WP_000495766.1 biofilm-dependent modulation protein -
APEC2908_RS07680 1558170..1558601 + 432 WP_000152310.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T288998 WP_000605675.1 NZ_LR740776:c1554188-1553910 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT288998 WP_000781370.1 NZ_LR740776:c1553910-1553626 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References