Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 543579..544258 Replicon chromosome
Accession NZ_LR740776
Organism Escherichia coli strain BEN2908 isolate

Toxin (Protein)


Gene name higB Uniprot ID V0VBP6
Locus tag APEC2908_RS02550 Protein ID WP_000057524.1
Coordinates 543579..543881 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag APEC2908_RS02555 Protein ID WP_000806442.1
Coordinates 543917..544258 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC2908_RS02525 538955..540607 + 1653 WP_021512190.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
APEC2908_RS02530 540645..541148 - 504 WP_000667000.1 hypothetical protein -
APEC2908_RS02535 541145..541945 - 801 WP_000439798.1 hypothetical protein -
APEC2908_RS02540 541969..542448 - 480 WP_000186633.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
APEC2908_RS02545 542652..543446 - 795 WP_000365177.1 TraB/GumN family protein -
APEC2908_RS02550 543579..543881 + 303 WP_000057524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APEC2908_RS02555 543917..544258 + 342 WP_000806442.1 HigA family addiction module antidote protein Antitoxin
APEC2908_RS02560 544316..546820 - 2505 WP_000083945.1 copper-exporting P-type ATPase CopA -
APEC2908_RS02565 547082..548014 + 933 WP_000883052.1 glutaminase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 540645..552859 12214


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11839.47 Da        Isoelectric Point: 10.2237

>T288997 WP_000057524.1 NZ_LR740776:543579-543881 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHWDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT288997 WP_000806442.1 NZ_LR740776:543917-544258 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0VBP6

Antitoxin

Source ID Structure
PDB 2EBY
AlphaFold DB S1QAY3

References