Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 303686..304380 Replicon chromosome
Accession NZ_LR740776
Organism Escherichia coli strain BEN2908 isolate

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag APEC2908_RS01405 Protein ID WP_001263500.1
Coordinates 303982..304380 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag APEC2908_RS01400 Protein ID WP_161476128.1
Coordinates 303686..303979 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC2908_RS01375 299222..299719 + 498 WP_000006241.1 REP-associated tyrosine transposase RayT -
APEC2908_RS01380 299802..299960 - 159 WP_014639450.1 hypothetical protein -
APEC2908_RS01385 300039..301751 - 1713 Protein_269 flagellar biosynthesis protein FlhA -
APEC2908_RS01390 301723..302508 + 786 WP_000207544.1 putative lateral flagellar export/assembly protein LafU -
APEC2908_RS01395 302579..303634 + 1056 WP_001226168.1 DNA polymerase IV -
APEC2908_RS01400 303686..303979 + 294 WP_161476128.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
APEC2908_RS01405 303982..304380 + 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
APEC2908_RS01410 304390..304842 + 453 WP_001059895.1 GNAT family N-acetyltransferase -
APEC2908_RS01415 305032..306171 + 1140 WP_000521577.1 RNA ligase RtcB family protein -
APEC2908_RS01420 306168..306782 + 615 WP_000602123.1 peptide chain release factor H -
APEC2908_RS01425 306839..308296 - 1458 WP_001292999.1 cytosol nonspecific dipeptidase -
APEC2908_RS01430 308557..309015 + 459 WP_001291988.1 xanthine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 284161..304842 20681


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T288995 WP_001263500.1 NZ_LR740776:303982-304380 [Escherichia coli]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11281.85 Da        Isoelectric Point: 5.8943

>AT288995 WP_161476128.1 NZ_LR740776:303686-303979 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDYFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PJQ2

Antitoxin

Source ID Structure

References