Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4454604..4455206 Replicon chromosome
Accession NZ_LR740758
Organism Escherichia coli strain BEN5202 isolate laying hen 51 weeks old

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag APEC5202_RS21680 Protein ID WP_000897302.1
Coordinates 4454604..4454915 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag APEC5202_RS21685 Protein ID WP_000356397.1
Coordinates 4454916..4455206 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC5202_RS21655 4450518..4451117 + 600 WP_001314324.1 glucose-1-phosphatase -
APEC5202_RS21660 4451111..4451983 + 873 WP_000920762.1 virulence factor BrkB family protein -
APEC5202_RS21665 4451980..4452417 + 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
APEC5202_RS21670 4452462..4453403 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
APEC5202_RS21675 4453467..4454375 - 909 WP_001331553.1 alpha/beta hydrolase -
APEC5202_RS21680 4454604..4454915 + 312 WP_000897302.1 hypothetical protein Toxin
APEC5202_RS21685 4454916..4455206 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
APEC5202_RS21690 4455565..4455843 + 279 WP_001296612.1 hypothetical protein -
APEC5202_RS21695 4456239..4456457 + 219 WP_001314326.1 ribbon-helix-helix domain-containing protein -
APEC5202_RS21700 4456673..4457602 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
APEC5202_RS21705 4457599..4458234 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
APEC5202_RS21710 4458231..4459133 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T288971 WP_000897302.1 NZ_LR740758:4454604-4454915 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT288971 WP_000356397.1 NZ_LR740758:4454916-4455206 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References