Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2092225..2092727 Replicon chromosome
Accession NZ_LR740758
Organism Escherichia coli strain BEN5202 isolate laying hen 51 weeks old

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag APEC5202_RS10330 Protein ID WP_000767829.1
Coordinates 2092225..2092479 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag APEC5202_RS10335 Protein ID WP_001259255.1
Coordinates 2092476..2092727 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC5202_RS10300 2087240..2087467 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
APEC5202_RS10305 2087481..2088539 - 1059 WP_000492340.1 transport protein YeeE -
APEC5202_RS10310 2088718..2090076 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
APEC5202_RS10315 2090066..2090128 - 63 WP_010723108.1 membrane protein YoeI -
APEC5202_RS10320 2090343..2091272 - 930 WP_000803351.1 LysR family transcriptional regulator -
APEC5202_RS10325 2091318..2092142 - 825 WP_000754737.1 SDR family oxidoreductase -
APEC5202_RS10330 2092225..2092479 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
APEC5202_RS10335 2092476..2092727 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
APEC5202_RS10340 2093010..2093060 + 51 WP_071593552.1 his operon leader peptide -
APEC5202_RS10345 2093206..2094105 + 900 WP_000131789.1 ATP phosphoribosyltransferase -
APEC5202_RS10350 2094111..2095415 + 1305 WP_001513845.1 histidinol dehydrogenase -
APEC5202_RS10355 2095412..2096482 + 1071 WP_000108943.1 histidinol-phosphate transaminase -
APEC5202_RS10360 2096482..2097549 + 1068 WP_001513846.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T288962 WP_000767829.1 NZ_LR740758:c2092479-2092225 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT288962 WP_001259255.1 NZ_LR740758:c2092727-2092476 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References