Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1684794..1685356 Replicon chromosome
Accession NZ_LR740758
Organism Escherichia coli strain BEN5202 isolate laying hen 51 weeks old

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag APEC5202_RS08185 Protein ID WP_000605675.1
Coordinates 1684794..1685072 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag APEC5202_RS08190 Protein ID WP_000781370.1
Coordinates 1685072..1685356 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC5202_RS08160 1680381..1680812 - 432 WP_000152310.1 peroxiredoxin OsmC -
APEC5202_RS08165 1681157..1681372 + 216 WP_000495766.1 biofilm-dependent modulation protein -
APEC5202_RS08170 1681474..1681611 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
APEC5202_RS08175 1681767..1683464 + 1698 WP_000433462.1 malate dehydrogenase -
APEC5202_RS08180 1683598..1684608 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
APEC5202_RS08185 1684794..1685072 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APEC5202_RS08190 1685072..1685356 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
APEC5202_RS08195 1685462..1686790 + 1329 WP_000547316.1 IS4-like element IS4 family transposase -
APEC5202_RS08200 1687024..1687677 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
APEC5202_RS08205 1687670..1688554 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1685462..1686790 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T288960 WP_000605675.1 NZ_LR740758:1684794-1685072 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT288960 WP_000781370.1 NZ_LR740758:1685072-1685356 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References