288954

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 505096..505775 Replicon chromosome
Accession NZ_LR740758
Organism Escherichia coli strain BEN5202 isolate laying hen 51 weeks old

Toxin (Protein)


Gene name higB Uniprot ID V0VBP6
Locus tag APEC5202_RS02350 Protein ID WP_000057524.1
Coordinates 505096..505398 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag APEC5202_RS02355 Protein ID WP_000806442.1
Coordinates 505434..505775 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APEC5202_RS02325 500472..502124 + 1653 WP_001513633.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
APEC5202_RS02330 502162..502665 - 504 WP_000667000.1 hypothetical protein -
APEC5202_RS02335 502662..503462 - 801 Protein_460 hypothetical protein -
APEC5202_RS02340 503486..503965 - 480 WP_000186633.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
APEC5202_RS02345 504169..504963 - 795 WP_000365177.1 TraB/GumN family protein -
APEC5202_RS02350 505096..505398 + 303 WP_000057524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APEC5202_RS02355 505434..505775 + 342 WP_000806442.1 HigA family addiction module antidote protein Antitoxin
APEC5202_RS02360 505833..508337 - 2505 WP_000083945.1 copper-exporting P-type ATPase CopA -
APEC5202_RS02365 508599..509531 + 933 WP_000883052.1 glutaminase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 502162..514373 12211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11839.47 Da        Isoelectric Point: 10.2237

>T288954 WP_000057524.1 NZ_LR740758:505096-505398 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHWDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT288954 WP_000806442.1 NZ_LR740758:505434-505775 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0VBP6

Antitoxin

Source ID Structure
AlphaFold DB S1QAY3

References