288949

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5420346..5420941 Replicon chromosome
Accession NZ_LR739071
Organism Pseudomonas aeruginosa strain C7-25 isolate C7-25

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PERCYII40_RS25055 Protein ID WP_003113526.1
Coordinates 5420663..5420941 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PERCYII40_RS25050 Protein ID WP_003113527.1
Coordinates 5420346..5420651 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PERCYII40_RS25015 5415483..5416331 + 849 WP_124171302.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PERCYII40_RS25025 5416498..5417439 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PERCYII40_RS25030 5417556..5418170 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PERCYII40_RS25035 5418214..5418798 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PERCYII40_RS25040 5418839..5419939 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PERCYII40_RS25050 5420346..5420651 - 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
PERCYII40_RS25055 5420663..5420941 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PERCYII40_RS25060 5421270..5423498 + 2229 WP_003099265.1 TonB-dependent receptor -
PERCYII40_RS25065 5423568..5424215 - 648 WP_003095021.1 carbonate dehydratase -
PERCYII40_RS25070 5424277..5425515 - 1239 WP_023084819.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T288949 WP_003113526.1 NZ_LR739071:c5420941-5420663 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT288949 WP_003113527.1 NZ_LR739071:c5420651-5420346 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References