288948

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4802796..4803477 Replicon chromosome
Accession NZ_LR739071
Organism Pseudomonas aeruginosa strain C7-25 isolate C7-25

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag PERCYII40_RS22240 Protein ID WP_003111825.1
Coordinates 4803112..4803477 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PERCYII40_RS22235 Protein ID WP_003145733.1
Coordinates 4802796..4803119 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PERCYII40_RS22210 4798709..4799347 + 639 WP_003109444.1 hypothetical protein -
PERCYII40_RS22215 4799590..4799925 + 336 WP_003140884.1 TM2 domain-containing protein -
PERCYII40_RS22220 4800099..4800617 + 519 WP_128654462.1 PAAR domain-containing protein -
PERCYII40_RS22225 4800614..4801315 + 702 WP_003111822.1 VRR-NUC domain-containing protein -
PERCYII40_RS22230 4801332..4802420 + 1089 WP_034025227.1 DUF3396 domain-containing protein -
PERCYII40_RS22235 4802796..4803119 - 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
PERCYII40_RS22240 4803112..4803477 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PERCYII40_RS22245 4803741..4803980 - 240 WP_049876884.1 hypothetical protein -
PERCYII40_RS22250 4804187..4804459 + 273 WP_003085667.1 hypothetical protein -
PERCYII40_RS22255 4804478..4804903 - 426 WP_003114206.1 ring-cleaving dioxygenase -
PERCYII40_RS22260 4805004..4805888 + 885 WP_128654463.1 LysR family transcriptional regulator -
PERCYII40_RS22265 4805861..4806814 - 954 WP_003085661.1 LysR family transcriptional regulator -
PERCYII40_RS22270 4807035..4807469 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T288948 WP_003111825.1 NZ_LR739071:c4803477-4803112 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT288948 WP_003145733.1 NZ_LR739071:c4803119-4802796 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure

References