Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5752799..5753394 Replicon chromosome
Accession NZ_LR739069
Organism Pseudomonas aeruginosa strain PcyII-40 isolate PcyII-40

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag G3R43_RS27065 Protein ID WP_003113526.1
Coordinates 5753116..5753394 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag G3R43_RS27060 Protein ID WP_003111575.1
Coordinates 5752799..5753104 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3R43_RS27025 5747939..5748787 + 849 WP_023096155.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
G3R43_RS27035 5748954..5749895 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
G3R43_RS27040 5750012..5750626 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
G3R43_RS27045 5750668..5751252 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
G3R43_RS27050 5751293..5752393 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
G3R43_RS27060 5752799..5753104 - 306 WP_003111575.1 HigA family addiction module antidote protein Antitoxin
G3R43_RS27065 5753116..5753394 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G3R43_RS27070 5753723..5755951 + 2229 WP_021264080.1 TonB-dependent receptor -
G3R43_RS27075 5756021..5756668 - 648 WP_003095021.1 carbonate dehydratase -
G3R43_RS27080 5756730..5757968 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T288941 WP_003113526.1 NZ_LR739069:c5753394-5753116 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT288941 WP_003111575.1 NZ_LR739069:c5753104-5752799 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References