288934

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5594933..5595528 Replicon chromosome
Accession NZ_LR739068
Organism Pseudomonas aeruginosa strain PcyII-29 isolate PcyII-29

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag G3R42_RS26040 Protein ID WP_003113526.1
Coordinates 5595250..5595528 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G3R42_RS26035 Protein ID WP_003099268.1
Coordinates 5594933..5595238 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3R42_RS26000 5590072..5590920 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
G3R42_RS26010 5591087..5592028 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
G3R42_RS26015 5592145..5592759 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
G3R42_RS26020 5592801..5593385 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
G3R42_RS26025 5593426..5594526 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
G3R42_RS26035 5594933..5595238 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
G3R42_RS26040 5595250..5595528 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G3R42_RS26045 5595857..5598085 + 2229 WP_003099265.1 TonB-dependent receptor -
G3R42_RS26050 5598155..5598802 - 648 WP_003095021.1 carbonate dehydratase -
G3R42_RS26055 5598864..5600102 - 1239 WP_003099263.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T288934 WP_003113526.1 NZ_LR739068:c5595528-5595250 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT288934 WP_003099268.1 NZ_LR739068:c5595238-5594933 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References