Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2002094..2002613 Replicon chromosome
Accession NZ_LR738724
Organism Streptococcus suis isolate 9401240

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8HQU0
Locus tag GPW69_RS09650 Protein ID WP_024384464.1
Coordinates 2002094..2002351 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0Z8KP98
Locus tag GPW69_RS09655 Protein ID WP_044763722.1
Coordinates 2002353..2002613 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW69_RS09640 1999168..2000898 - 1731 WP_074391593.1 hypothetical protein -
GPW69_RS09645 2001106..2001978 - 873 WP_074391592.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
GPW69_RS09650 2002094..2002351 - 258 WP_024384464.1 Txe/YoeB family addiction module toxin Toxin
GPW69_RS09655 2002353..2002613 - 261 WP_044763722.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPW69_RS09660 2003289..2003744 - 456 WP_044763723.1 8-oxo-dGTP diphosphatase -
GPW69_RS09665 2003764..2004282 - 519 WP_044763724.1 DUF3916 domain-containing protein -
GPW69_RS09670 2004279..2004860 - 582 WP_044763725.1 ribonuclease M5 -
GPW69_RS09675 2004844..2005626 - 783 WP_074391591.1 TatD family hydrolase -
GPW69_RS09680 2005733..2005870 - 138 WP_002939016.1 50S ribosomal protein L34 -
GPW69_RS09685 2006038..2007033 - 996 WP_013730624.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10261.75 Da        Isoelectric Point: 7.2737

>T288927 WP_024384464.1 NZ_LR738724:c2002351-2002094 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.32 Da        Isoelectric Point: 5.1255

>AT288927 WP_044763722.1 NZ_LR738724:c2002613-2002353 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLTVARNTYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8HQU0

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8KP98

References