Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2056978..2057497 Replicon chromosome
Accession NZ_LR738723
Organism Streptococcus suis isolate GD-0088

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag GPW68_RS10240 Protein ID WP_012775363.1
Coordinates 2056978..2057235 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag GPW68_RS10245 Protein ID WP_002939010.1
Coordinates 2057237..2057497 (-) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW68_RS10225 2053447..2055177 - 1731 WP_012775361.1 membrane protein -
GPW68_RS10230 2055542..2056450 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
GPW68_RS10235 2056434..2056964 - 531 WP_009910909.1 DUF1697 domain-containing protein -
GPW68_RS10240 2056978..2057235 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
GPW68_RS10245 2057237..2057497 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPW68_RS10250 2057573..2058028 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
GPW68_RS10255 2058035..2058364 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPW68_RS10260 2058354..2058641 - 288 WP_012028535.1 hypothetical protein -
GPW68_RS10265 2058739..2059107 - 369 WP_012775453.1 hypothetical protein -
GPW68_RS10270 2059100..2059669 - 570 WP_012775700.1 ribonuclease M5 -
GPW68_RS10275 2059653..2060435 - 783 WP_012028536.1 TatD family hydrolase -
GPW68_RS10280 2060542..2060679 - 138 WP_002939016.1 50S ribosomal protein L34 -
GPW68_RS10285 2060847..2061842 - 996 WP_012775367.1 protein jag -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2035232..2060435 25203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-84)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T288919 WP_012775363.1 NZ_LR738723:c2057235-2056978 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp


Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT288919 WP_002939010.1 NZ_LR738723:c2057497-2057237 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6


Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References