Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1932238..1932757 Replicon chromosome
Accession NZ_LR738720
Organism Streptococcus suis isolate GD-0001

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag GPW48_RS09700 Protein ID WP_012775363.1
Coordinates 1932238..1932495 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag GPW48_RS09705 Protein ID WP_002939010.1
Coordinates 1932497..1932757 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW48_RS09680 1927959..1929689 - 1731 WP_024387386.1 membrane protein -
GPW48_RS09685 1930150..1930623 - 474 WP_024378560.1 IS200/IS605 family transposase -
GPW48_RS09690 1930803..1931675 - 873 WP_024387385.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
GPW48_RS09695 1931694..1932224 - 531 WP_074390182.1 DUF1697 domain-containing protein -
GPW48_RS09700 1932238..1932495 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
GPW48_RS09705 1932497..1932757 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPW48_RS09710 1932833..1933288 - 456 WP_074390181.1 8-oxo-dGTP diphosphatase -
GPW48_RS09720 1933387..1933722 - 336 Protein_1833 toprim domain-containing protein -
GPW48_RS09725 1933706..1934488 - 783 WP_012028536.1 TatD family hydrolase -
GPW48_RS09730 1934595..1934732 - 138 WP_002939016.1 50S ribosomal protein L34 -
GPW48_RS09735 1934900..1935895 - 996 WP_012775367.1 protein jag -
GPW48_RS09740 1935915..1936727 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
GPW48_RS09745 1936711..1937070 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1908815..1934488 25673
- flank IS/Tn - - 1930150..1930623 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T288901 WP_012775363.1 NZ_LR738720:c1932495-1932238 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT288901 WP_002939010.1 NZ_LR738720:c1932757-1932497 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References