Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4816115..4816781 Replicon chromosome
Accession NZ_LR699014
Organism Citrobacter werkmanii isolate MGYG-HGUT-02535

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FYC27_RS23235 Protein ID WP_096759269.1
Coordinates 4816464..4816781 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag FYC27_RS23230 Protein ID WP_003837894.1
Coordinates 4816115..4816411 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC27_RS23215 4813291..4813764 - 474 WP_003023524.1 transcription elongation factor GreB -
FYC27_RS23220 4813991..4814710 + 720 WP_001157751.1 two-component system response regulator OmpR -
FYC27_RS23225 4814707..4816059 + 1353 WP_096759268.1 two-component system sensor histidine kinase EnvZ -
FYC27_RS23230 4816115..4816411 - 297 WP_003837894.1 helix-turn-helix domain-containing protein Antitoxin
FYC27_RS23235 4816464..4816781 - 318 WP_096759269.1 toxin HigB-2 Toxin
FYC27_RS23240 4816905..4818527 - 1623 WP_096759270.1 phosphoenolpyruvate carboxykinase (ATP) -
FYC27_RS23245 4818906..4820624 + 1719 WP_096759271.1 DUF4153 domain-containing protein -
FYC27_RS23250 4820675..4821553 - 879 WP_096759272.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12213.13 Da        Isoelectric Point: 9.8310

>T288795 WP_096759269.1 NZ_LR699014:c4816781-4816464 [Citrobacter werkmanii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIETPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSDMLI

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT288795 WP_003837894.1 NZ_LR699014:c4816411-4816115 [Citrobacter werkmanii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References