Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4577374..4578026 Replicon chromosome
Accession NZ_LR699009
Organism Pluralibacter gergoviae isolate MGYG-HGUT-02520

Toxin (Protein)


Gene name higB Uniprot ID A0A1Y4Y846
Locus tag FYC31_RS21545 Protein ID WP_045289934.1
Coordinates 4577670..4578026 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A089PP79
Locus tag FYC31_RS21540 Protein ID WP_043082872.1
Coordinates 4577374..4577673 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC31_RS21525 4572522..4574819 - 2298 WP_048253925.1 beta-glucosidase BglX -
FYC31_RS21530 4575026..4576753 + 1728 WP_048253924.1 D-lactate dehydrogenase -
FYC31_RS21535 4576757..4577311 + 555 WP_043082873.1 GNAT family N-acetyltransferase -
FYC31_RS21540 4577374..4577673 - 300 WP_043082872.1 helix-turn-helix transcriptional regulator Antitoxin
FYC31_RS21545 4577670..4578026 - 357 WP_045289934.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYC31_RS21550 4578209..4579153 - 945 WP_048253923.1 D-alanyl-D-alanine endopeptidase -
FYC31_RS21555 4579320..4579907 - 588 WP_048253922.1 YIP1 family protein -
FYC31_RS21560 4580082..4580657 + 576 WP_048253921.1 DedA family protein -
FYC31_RS21565 4580748..4581515 - 768 WP_048253920.1 SDR family oxidoreductase -
FYC31_RS21570 4581623..4582357 + 735 WP_043082867.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13802.74 Da        Isoelectric Point: 8.8875

>T288768 WP_045289934.1 NZ_LR699009:c4578026-4577670 [Pluralibacter gergoviae]
MWTVLFSQRFDDWLSEQEEALQEKVLADLGKLKAYGPNLPRPHADTLKGSRYNNMKELRIQFAGRPVRAFYAFDPVRHAI
VLCAGDKSSDKQFYDRMIRIADDEFSAHLARQEKEKIR

Download         Length: 357 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10927.73 Da        Isoelectric Point: 6.3606

>AT288768 WP_043082872.1 NZ_LR699009:c4577673-4577374 [Pluralibacter gergoviae]
MRTLDDAIASRSAQSQARIKEMTDEMVLEVGLQLMREELQLSQKALAEAMGVRQPAIAQIEQRGNDLKIATLKRYVEAMG
GKLSLDVELPGGKKVAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y4Y846

Antitoxin

Source ID Structure
AlphaFold DB A0A089PP79

References