Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3737851..3738413 Replicon chromosome
Accession NZ_LR699006
Organism Citrobacter freundii isolate MGYG-HGUT-02495

Toxin (Protein)


Gene name higB Uniprot ID A0A1C0NXV4
Locus tag FYB80_RS17775 Protein ID WP_003833016.1
Coordinates 3738135..3738413 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FYB80_RS17770 Protein ID WP_047411217.1
Coordinates 3737851..3738135 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB80_RS17755 3735541..3736425 + 885 WP_003833024.1 formate dehydrogenase N subunit beta -
FYB80_RS17760 3736418..3737074 + 657 WP_003020054.1 formate dehydrogenase-N subunit gamma -
FYB80_RS17765 3737204..3737803 + 600 WP_047411210.1 inorganic diphosphatase -
FYB80_RS17770 3737851..3738135 - 285 WP_047411217.1 HigA family addiction module antidote protein Antitoxin
FYB80_RS17775 3738135..3738413 - 279 WP_003833016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYB80_RS17780 3738634..3740349 - 1716 WP_047411222.1 ATP-binding cassette domain-containing protein -
FYB80_RS17785 3740814..3741716 + 903 WP_043016304.1 endonuclease/exonuclease/phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10667.30 Da        Isoelectric Point: 9.8965

>T288736 WP_003833016.1 NZ_LR699006:c3738413-3738135 [Citrobacter freundii]
MIMNFRHKGLRDLFLHGRTSGVMAKHVRRLRHRLAVIDAASKVTDINMPGYKLHPLVGERDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10357.03 Da        Isoelectric Point: 10.1834

>AT288736 WP_047411217.1 NZ_LR699006:c3738135-3737851 [Citrobacter freundii]
MKMANHPRPGDIIQEALNELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNSWSLAEAQ
KNVDTSRLRKLAVQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0NXV4

Antitoxin

Source ID Structure

References