Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 956901..957500 Replicon chromosome
Accession NZ_LR699006
Organism Citrobacter freundii isolate MGYG-HGUT-02495

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FYB80_RS04605 Protein ID WP_047407483.1
Coordinates 957189..957500 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FYB80_RS04600 Protein ID WP_047407480.1
Coordinates 956901..957188 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB80_RS04585 954397..955299 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
FYB80_RS04590 955296..955931 + 636 WP_047407477.1 formate dehydrogenase cytochrome b556 subunit -
FYB80_RS04595 955928..956857 + 930 WP_043018887.1 formate dehydrogenase accessory protein FdhE -
FYB80_RS04600 956901..957188 - 288 WP_047407480.1 helix-turn-helix domain-containing protein Antitoxin
FYB80_RS04605 957189..957500 - 312 WP_047407483.1 hypothetical protein Toxin
FYB80_RS04610 957721..958629 + 909 WP_047407486.1 alpha/beta hydrolase -
FYB80_RS04615 958694..958936 + 243 WP_003825282.1 type II toxin-antitoxin system ParD family antitoxin -
FYB80_RS04620 958929..959216 + 288 WP_003825284.1 type II toxin-antitoxin system RelE/ParE family toxin -
FYB80_RS04625 959222..960163 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
FYB80_RS04630 960208..960645 - 438 WP_003028671.1 D-tyrosyl-tRNA(Tyr) deacylase -
FYB80_RS04635 960642..961514 - 873 WP_047407489.1 virulence factor BrkB family protein -
FYB80_RS04640 961508..962107 - 600 WP_043018883.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12270.39 Da        Isoelectric Point: 10.0972

>T288726 WP_047407483.1 NZ_LR699006:c957500-957189 [Citrobacter freundii]
MLFIETEIFTEDVKKLLDDDEYRRLQIFLTIQPDCGDLIHDTGGLRKVRWRARGKGKRGGVRIIYFHQIRKSQIRLLLIY
QKGIKDDLTPQEKVLLRMLNEGW

Download         Length: 312 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10819.40 Da        Isoelectric Point: 10.8907

>AT288726 WP_047407480.1 NZ_LR699006:c957188-956901 [Citrobacter freundii]
MDKALFERLTQSMIQMNEIDEGTRQPSRTFHIDAMKIKEIRQSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References