Detailed information of TA system TA288674

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2720648..2720974
• Replicon: chromosome
• Accession: NZ_LR698844
• Organism: Enterococcus faecalis isolate MGYG-HGUT-01694

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: FXY61_RS13320
• Protein ID: WP_073340360.1
• Coordinates: 2720834..2720974 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2720648..2720832 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXY61_RS13295	2715687..2715902	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
FXY61_RS13300	2716041..2717033	+	993	WP_002389493.1	biotin--[acetyl-CoA-carboxylase] ligase	-
FXY61_RS13305	2717297..2717935	-	639	WP_015212268.1	lytic polysaccharide monooxygenase	-
FXY61_RS13310	2718621..2720237	+	1617	WP_015212269.1	phosphatase PAP2/LCP family protein	-
FXY61_RS13315	2720566..2720715	+	150	WP_002411240.1	putative holin-like toxin	-
-	2720648..2720832	-	185	-	-	Antitoxin
FXY61_RS13320	2720834..2720974	+	141	WP_073340360.1	putative holin-like toxin	Toxin
FXY61_RS13325	2721205..2721348	+	144	WP_002381035.1	putative holin-like toxin	-
FXY61_RS13330	2721543..2725370	-	3828	WP_002389430.1	WxL domain-containing protein	-
FXY61_RS13335	2725357..2725719	-	363	WP_002378868.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T288674 WP_073340360.1 NZ_LR698844:2720834-2720974 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

Antitoxin

Nucleotide

• Length: 185 bp

>AT288674 NZ_LR698844:c2720832-2720648 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin