Detailed information of TA system TA288666

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2566305..2566591
• Replicon: chromosome
• Accession: NZ_LR698844
• Organism: Enterococcus faecalis isolate MGYG-HGUT-01694

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: FXY61_RS12620
• Protein ID: WP_002393909.1
• Coordinates: 2566463..2566591 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2566305..2566514 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXY61_RS12590	2561558..2562511	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
FXY61_RS12595	2562550..2563305	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
FXY61_RS12600	2563302..2564267	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
FXY61_RS12605	2564264..2565211	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
FXY61_RS12610	2565396..2565848	+	453	WP_002389410.1	YueI family protein	-
FXY61_RS12615	2566030..2566157	-	128	Protein_2454	putative holin-like toxin	-
-	2566305..2566514	+	210	-	-	Antitoxin
FXY61_RS12620	2566463..2566591	-	129	WP_002393909.1	hypothetical protein	Toxin
FXY61_RS12625	2566754..2569024	-	2271	WP_002389492.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
FXY61_RS12630	2569195..2569695	+	501	WP_002372831.1	cysteine hydrolase	-
FXY61_RS12635	2570094..2570990	+	897	WP_002389477.1	YitT family protein	-
FXY61_RS12640	2571041..2571439	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T288666 WP_002393909.1 NZ_LR698844:c2566591-2566463 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

Antitoxin

Nucleotide

• Length: 210 bp

>AT288666 NZ_LR698844:2566305-2566514 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin