288640

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1329439..1330090 Replicon chromosome
Accession NZ_LR595857
Organism Streptococcus sp. NCTC 11567 strain NCTC11567

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FQT67_RS06670 Protein ID WP_046177189.1
Coordinates 1329725..1330090 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FQT67_RS06665 Protein ID WP_027971722.1
Coordinates 1329439..1329735 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQT67_RS06645 1324749..1325813 - 1065 WP_046177187.1 streptolysin associated protein SagC -
FQT67_RS06650 1325810..1326760 - 951 WP_003061458.1 SagB family peptide dehydrogenase -
FQT67_RS06655 1326979..1327140 - 162 WP_012766767.1 TOMM family cytolysin streptolysin S -
FQT67_RS10775 1328038..1328205 - 168 WP_165626014.1 hypothetical protein -
FQT67_RS06660 1328212..1329417 - 1206 WP_046177188.1 hypothetical protein -
FQT67_RS06665 1329439..1329735 - 297 WP_027971722.1 helix-turn-helix transcriptional regulator Antitoxin
FQT67_RS06670 1329725..1330090 - 366 WP_046177189.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FQT67_RS06675 1330308..1330703 - 396 WP_046177190.1 hypothetical protein -
FQT67_RS06680 1330721..1331047 - 327 WP_046177191.1 hypothetical protein -
FQT67_RS06685 1331040..1331468 - 429 WP_053042316.1 hypothetical protein -
FQT67_RS06690 1331507..1331794 - 288 WP_046177192.1 hypothetical protein -
FQT67_RS06695 1331791..1332183 - 393 Protein_1261 hypothetical protein -
FQT67_RS06700 1332264..1333408 + 1145 WP_115256952.1 IS3 family transposase -
FQT67_RS06705 1333443..1333631 - 189 Protein_1263 hypothetical protein -
FQT67_RS06710 1333729..1333911 - 183 WP_000273649.1 hypothetical protein -
FQT67_RS06715 1334161..1335045 - 885 WP_053042318.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sagA 1322046..1349112 27066


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14390.55 Da        Isoelectric Point: 9.7920

>T288640 WP_046177189.1 NZ_LR595857:c1330090-1329725 [Streptococcus sp. NCTC 11567]
VHNIYFYKDKNGNEPVLDYMRELASKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRILFVAWI
DGSFVLLHHFMKKTQKTPKREIDQAKRELADLKERGLDNEK

Download         Length: 366 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10758.43 Da        Isoelectric Point: 4.8898

>AT288640 WP_027971722.1 NZ_LR595857:c1329735-1329439 [Streptococcus sp. NCTC 11567]
MKNNAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEEMSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPIEGEQVS

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References