Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1642370..1642882 Replicon chromosome
Accession NZ_LR595848
Organism Streptococcus pneumoniae strain 4559 isolate 4559

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag FJH52_RS08165 Protein ID WP_000924721.1
Coordinates 1642370..1642624 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag FJH52_RS08170 Protein ID WP_000388572.1
Coordinates 1642628..1642882 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJH52_RS08145 1637697..1638011 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
FJH52_RS08150 1638036..1638662 - 627 WP_000775037.1 guanylate kinase -
FJH52_RS08155 1638792..1640405 - 1614 WP_000404940.1 ribonuclease Y -
FJH52_RS08160 1640600..1641997 + 1398 WP_084588706.1 ISNCY family transposase -
FJH52_RS08165 1642370..1642624 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
FJH52_RS08170 1642628..1642882 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FJH52_RS08175 1643120..1644217 - 1098 WP_000156330.1 nucleotidyltransferase -
FJH52_RS08180 1644227..1644973 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
FJH52_RS08185 1645076..1645429 - 354 WP_001003001.1 ribosome silencing factor -
FJH52_RS08190 1645442..1645942 - 501 WP_000844713.1 cysteine hydrolase -
FJH52_RS08195 1645943..1646536 - 594 WP_000121651.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
FJH52_RS08200 1646536..1647165 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
FJH52_RS08205 1647217..1647528 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1640600..1641997 1397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T288625 WP_000924721.1 NZ_LR595848:c1642624-1642370 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT288625 WP_000388572.1 NZ_LR595848:c1642882-1642628 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References