Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3194030..3194723 Replicon chromosome
Accession NZ_LR595691
Organism Escherichia coli isolate EcMAD1

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag ECMAD3_RS15435 Protein ID WP_000415585.1
Coordinates 3194427..3194723 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag ECMAD3_RS15430 Protein ID WP_000650107.1
Coordinates 3194030..3194425 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECMAD3_RS15420 3189894..3192152 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
ECMAD3_RS15425 3192290..3193897 - 1608 WP_001375094.1 ABC transporter substrate-binding protein -
ECMAD3_RS15430 3194030..3194425 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
ECMAD3_RS15435 3194427..3194723 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
ECMAD3_RS15440 3194928..3195410 - 483 WP_000183505.1 transcriptional regulator -
ECMAD3_RS15445 3195463..3195855 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
ECMAD3_RS15450 3196007..3196666 + 660 WP_001221502.1 two-component system response regulator QseB -
ECMAD3_RS15455 3196663..3198012 + 1350 WP_000673358.1 two-component system sensor histidine kinase QseC -
ECMAD3_RS15460 3198058..3198390 - 333 WP_000914690.1 DUF2645 family protein -
ECMAD3_RS15465 3198397..3199589 - 1193 Protein_2984 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T288611 WP_000415585.1 NZ_LR595691:c3194723-3194427 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT288611 WP_000650107.1 NZ_LR595691:c3194425-3194030 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References