Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2120381..2120883 Replicon chromosome
Accession NZ_LR595691
Organism Escherichia coli isolate EcMAD1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag ECMAD3_RS10410 Protein ID WP_000767829.1
Coordinates 2120381..2120635 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ECMAD3_RS10415 Protein ID WP_001259255.1
Coordinates 2120632..2120883 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECMAD3_RS10380 2115396..2115623 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
ECMAD3_RS10385 2115637..2116695 - 1059 WP_000492346.1 transport protein YeeE -
ECMAD3_RS10390 2116874..2118232 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
ECMAD3_RS10395 2118222..2118284 - 63 WP_010723108.1 membrane protein YoeI -
ECMAD3_RS10400 2118499..2119428 - 930 WP_000803351.1 LysR family transcriptional regulator -
ECMAD3_RS10405 2119474..2120298 - 825 WP_000754758.1 SDR family oxidoreductase -
ECMAD3_RS10410 2120381..2120635 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ECMAD3_RS10415 2120632..2120883 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ECMAD3_RS10420 2121167..2121217 + 51 WP_001364200.1 his operon leader peptide -
ECMAD3_RS10425 2121363..2122262 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
ECMAD3_RS10430 2122268..2123572 + 1305 WP_001317939.1 histidinol dehydrogenase -
ECMAD3_RS10435 2123569..2124639 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
ECMAD3_RS10440 2124639..2125706 + 1068 WP_000080060.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T288606 WP_000767829.1 NZ_LR595691:c2120635-2120381 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT288606 WP_001259255.1 NZ_LR595691:c2120883-2120632 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References